The Titanic Ant is the third fought boss in Earthbound (after Frank and Frankystein Mark II), and the first boss of a Your Sanctuary location, this one being Giant Step. This enemy requires to be checked to be fought, as with any other boss of a Your Sanctuary location.
When battle is initiated with the boss, it will have two Black Antoid allies that enter battle with it. These two Black Antoids will cast Lifeup α, even if it isn't needed. One shot of PSI Special will dispose of the two flunkies.